Tranexamic Acid: the science behind melan tran3x
Mesoestetic® is an internationally renowned pharmaceutical and skincare manufacturer, a global specialist in skin depigmentation. They are impressive brand behind cosmelan®, and in 2018, they launched melan tran3x, based on the active ingredient tranexamic acid.

Melan tran3x by mesoestetic
Many individuals dealing with melasma or hyperpigmentation are familiar with the mesoestetic melan tran3x kit. The complete melan tran3x protocol comprises both professional solutions and homecare products. Combining both the in-clinic treatment protocol and the homecare kit leads to improved results.
Did you know? Tranexamic Acid is the primary active ingredient in the melan tran3x treatment, it works by inhibiting the plasminogen/plasmin pathway, thereby reducing the interaction between melanocytes and keratinocytes. Melanocytes are responsible for producing melanin, the pigment responsible for skin coloration. By modulating this interaction, tranexamic acid helps to regulate melanin production and minimise the appearance of pigmentation and melasma.
The melan tran3x treatment
- melanostop tran3x peel: Within their professional solutions range, is the mesopeel® melanostop tran3x, a chemical peel with a formula that accelerates epidermal renewal to eliminate the superficial accumulation of melanin.
- c.prof 210 depigmentation solution: following the peel, their potent, c.prof 210 solution, is applied.
- m-pen skin needling: this transcutaneous solution is superficially needled into the skin, and helps to regulate the production of melanin presented in epidermal cells.
Understanding the causes of Hyperpigmentation
Hyperpigmentation results from an excess production of melanin, the pigment responsible for the color of our skin, hair, and eyes. This condition can be triggered by various factors, including exposure to sunlight, hormonal fluctuations (such as those occurring during pregnancy or with the use of hormonal contraceptives), inflammation, and skin injuries. It can affect individuals of all skin types and tones.
Treatment indications
The melan tran3x homecare kit and in-clinic treatments are indicated for:
- Melasma: Moderate to mild hormonal hyperpigmentation.
- Sun-damage: Moderate to mild sun-induced hyperpigmentation.
- PIH: Post-inflammatory hyperpigmentation.
- Maintenance: managing the reappearance of melasma, sun damage, and PIH, especially after completing advanced treatments like cosmelan.

Infusing sterile actives with the m-pen device by mesoestetic.
The science behind tran3x
Tranexamic Acid, the primary active ingredient in the melan tran3x treatment, works by inhibiting the plasminogen/plasmin pathway, thereby reducing the interaction between melanocytes and keratinocytes. Melanocytes are responsible for producing melanin, the pigment responsible for skin coloration. By modulating this interaction, tranexamic acid helps to regulate melanin production and minimize the appearance of hyperpigmentation.

Melan Tran3x Kit
The mesoestetic melan tran3x homecare treatment kit includes their melan tran3x concentrate serum, melan tran3x gel-cream, and the most advanced medical-grade SPF available on the market to date—specially formulated for melasma and other hyperpigmentation disorders—mesoestetic’s mesoprotech melan 130+ pigment control.
Available in-clinic at all Natural Aesthetics branches, as well as on our online store, Skin Spot. Follow the link to read more about the mesoestetic melan tran3x kit.
Meet our therapists
Our highly skilled team of medically trained aesthetic therapists specialises in providing personalised Dermapen treatments tailored to address your specific skincare concerns – across our clinics in Cape Town in Somerset West.






Before & After Results
At Natural Aesthetics, we have witnessed remarkable transformations through the melan tran3x treatment protocol.

Hormonal hyperpigmentation and melasma marks were significantly reduced after only three sessions of our customized tran3x peel and c.prof 210 solution-induced microneedling treatments. These treatments have provided our patient with rejuvenated skin and a noticeably more even complexion.

Dark spots and blemishes have been beautifully reduced, resulting in a brighter and more even skin tone, showcasing a luminous and healthy complexion. These remarkable improvements are seen before and after completing a course of Tranex peel and microneedling treatments.

Transformed from dull, aged, and sun-damaged skin to an even, rejuvenated complexion with a radiant glow. These changes occurred within just one month.

Glowing skin with a clear even skin tone after only 1 tranex peel & microneedling treatment.

Inflamed skin, red marks and hyperpigmentation lifted after only one of our bespoke tranex peel & microneedling combination treatments.

Results achieved through a course of melan tran3x treatments, combined with the use of carefully melan tran3x kit.

Prepaid Course
Earn loyalty points on all mesoestetic products, as well as on all mesoestetic and cosmelan professional treatments. Available across all Natural Aesthetics clinics, Green Point, Tyger Valley and Somerset West.
For those seeking a comprehensive depigmentation solution, we offer a prepaid course that consists of the full mesoestetic melan tran3x homecare kit as well as five in-clinic melan tran3x treatments at an all-inclusive cost of R10,000 (you save R1,865 in total).
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At Natural Aesthetics, we blend medical expertise with aesthetic innovation to offer a comprehensive range of weight loss, skincare, hair removal, and non-surgical aesthetic treatments. Our qualified team of medical doctors and aesthetic therapists is dedicated to delivering personalised solutions that enhance your natural beauty. Beyond our treatments, we proudly offer an extensive collection of top-tier local and international medical-grade skincare products, available across our established clinics in Green Point, Tyger Valley, and Somerset West, as well as via our popular online store, Skin Spot. Experience the perfect synergy of medical science and holistic beauty at Natural Aesthetics. Join our beauty and skincare community today!