Cosmelan is a professional depigmentation treatment developed by Mesoestetic to combat skin discolouration caused by melanin imbalances. Known for its powerful results, the Cosmelan peel minimises dark spots, melasma, and post-inflammatory hyperpigmentation while promoting skin renewal. This advanced treatment is suitable for all skin types, making it a versatile solution for anyone looking to enhance their skin’s clarity and radiance.
At Natural Aesthetics, one of Cape Town’s leading skincare and aesthetic medicine specialists, we can help you discover radiant, even-toned skin with Mesoestetic Cosmelan treatments.
The Cosmelan depigmentation peel works by inhibiting tyrosinase, an enzyme involved in melanin production. By regulating melanin synthesis, it significantly reduces the appearance of pigmentation while preventing new spots from forming. The treatment begins with a Mesoestetic peel booster, which prepares the skin for optimal absorption, followed by the application of the Cosmelan mask. After a set duration, the mask is removed at home, and the patient continues with homecare using the Cosmelan 2 maintenance cream after 5 – 7 days. This dual-action approach ensures both immediate and long-term results.
Cosmelan peels stand out as one of the most effective depigmentation solutions on the market. Unlike traditional treatments, such as chemical peels or laser therapy, Mesoestetic treatments target the root cause of hyperpigmentation—melanin overproduction—while offering a gentle, non-invasive approach. Additional benefits include:
At Natural Aesthetics, our skilled professionals customise the Cosmelan experience to meet your unique skincare needs, ensuring a safe and effective treatment journey.
When undergoing Cosmelan® treatment at our clinic, you can expect the following:
1 Week Before Your Treatment:
Preparing for the Cosmelan® Procedure
Application of Cosmelan 1 Mask:
Removal of Cosmelan 1 Mask (Completed at Home by the Patient):
Proper aftercare is essential for achieving and maintaining the best results from your Cosmelan® treatment. Here’s how to use Cosmelan 2 and Mesoestetic homecare products to ensure optimal recovery and skin health.
Month 1:
After the initial 5-7 day recovery period, you will begin your Cosmelan 2 regimen, which includes a 3x daily application for one month:
Month 2-3:
During the second and third months, you will adjust the frequency of your applications:
Month 4-6:
As you move into the maintenance phase (months 4-6), the regimen simplifies:
Important to Remember:
The Cosmelan treatment involves three distinct phases. The Preparation Phase is priced at R5,500, followed by the application of the Cosmelan Mask and Homecare Kit, which costs R15,750. To ensure optimal long-term results, the Maintenance Phase Kit is available at R8,960.
Prep phase | R5,500 |
Cosmelan Mask & Homecare Kit | R15,750 |
Maintenance Phase Kit | R8,960 |
Mesoestetic is a globally recognised leader in the field of dermatological and medical-grade skincare treatments and solutions. Founded over 30 years ago, the company has established itself as a pioneer in the development of innovative skincare solutions that are both scientifically advanced and highly effective. Mesoestetic is known for its commitment to rigorous research, cutting-edge technology, and the highest standards of quality and safety in the industry.
Cosmelan® is one of the world’s leading depigmentation methods that gently targets and treats unwanted pigmentation on the face and body. The two-phase intensive treatment programme safely corrects all stages of the hyperpigmentation process, fading the appearance of existing and stubborn pigmentation as well as maintains and prevents the formation of future pigmentation
Mesoestetic Peels are a non-invasive cosmetic procedure designed to
improve skin health and address various skin concerns using chemicalpeels developed by Mesoestetic, a renowned skincare brand. These peels are highly effective in promoting skin rejuvenation, treating specific skin conditions, and achieving a healthier and more radiant complexion.
Mesoestetic Peels promote collagen production, reducing the appearance of fine lines and wrinkles. With customizable options, Mesoestetic® Mesopeels offer a personalized approach to address specific skin concerns and achieve a more youthful complexion.
Mesoestetic Peels can significantly reduce the appearance of pigmentation issues, such as sunspots and melasma. The chemical solution exfoliates the top layers of the skin, removing dead skin cells, and stimulating the regeneration of new, healthier skin.
Cosmelan is one of the world’s leading depigmentation methods that gently targets and treats unwanted pigmentation on the face and body. The two-phase intensive treatment programme safely corrects all stages of the hyperpigmentation process, fading the appearance of existing and stubborn pigmentation as well as maintains and prevents the formation of future pigmentation.
Cosmelan 2 is a homecare maintenance cream that complements the in-office treatment. It helps sustain results by continuing to regulate melanin production and preventing the reappearance of pigmentation. You need to apply it 3 times a day after the initial 5 – 7 day recovery period.
The Cosmelan treatment delivers a brighter, more even complexion while reducing dark spots and pigmentation. It also enhances skin texture and boosts confidence by providing a noticeable transformation.
The Most common types of pigmentation treated with Cosmelan are:
Cosmelan may safely be performed on patients of all ages and ethnicities who are struggling with stubborn pigmentation. This treatment is particularly effective on melasma, a form of hormonally stimulated pigmentation. Book a consultation with one of our experienced Aesthetic therapists and they will guide you with the most appropriate treatment plan for your skin.
The in-office procedure typically takes about 30-45 minutes. The mask remains on your skin for several hours, depending on your skin type and condition, and is removed at home.
Most patients see significant improvement after one treatment. However, results vary, and maintenance with Cosmelan 2 is essential for long-lasting effects.
Next day – 4 days
You may start wearing eye make-up immediately but please wait at least 1 week after mask removal and only once your skin has stopped peeling to wear foundation or concealer.
The Melan Protech 130+ SPF does help to cover some of the redness on the skin.
There is no real cure for hyperpigmentation. Epidermal pigmentation may see good to excellent results whilst deeper dermal pigmentation may see fair to moderate results. It is a management process that depends on your commitment to the phases of the Cosmelan Protocol. Failure to persist with the treatment may lead to the reappearance of dark spots.
No–Unfortunately you cannot be on Cosmelan as there are high doses of retinol and salicylic acid in the Cosmelan products.
Topical or oral treatment with isotretinoin, sun-sensitising anti-biotics, hydroquinone, active bacterial, viral, fungal or herpes infection. You have to wait 6 months after topical hydroquinone or oral isotretinoin before starting with Cosmelan.
Preparation Phase- NON-NEGOTIABLE preparation of the skin must be done with Melan 130+ SPF 50 as well as the Mesoestetic Brightening peel Booster. You will use these 2 products at home to prepare your skin for the Cosmelan mask.
Skin Types I-III: 4 week prep
Skin Types IV-VI: 6 Week Prep
Optional: Melanostop Tran3X Peel 48 hours prior to mask application.
Correction Phase- This is done in the clinic by the Aesthetic Therapist. It involves the application of the Cosmelan 1 mask.
Homecare Recovery- This is the 5-7 days post removal of Cosmelan 1 mask. DO NOT APPLY COSMELAN 2 during these 5-7 days! You may flake 2-3 days after the mask so you may ease the flaking with; Melan Recovery, Fast Skin repair or the anti-stress mask.
3 Part Regulation Phase- This is your home treatment with Cosmelan 2 Maintenance cream and skin care.
| 1 month after clinic treatment (3x a day application) | 2nd to 3rd month after clinic treatment | 4th to 12th month after clinic treatment. |
Continuous depigmentation
Optional: Anti- Stress Mask | Pigmentation regulation
Optional: Anti- Stress Mask | Reappearance Control
Optional: Anti- Stress Mask |
If you stop after 3 months of the regulation phase then you have not given your skin enough time to calm and reprogram the melanocytes and we find that patients do not see the desired results. Please commit to completing all the phases as per the protocol.
Patients often describe a sensation of heat and stinging. This is all normal.
Cosmelan does not contain hydroquinone or trichloroacetic acid. It is safe for all skin types and safe for our hot South African Climate.
You may use a misting/spray bottle and mist the mask with water to prevent the mask from drying to soon.
8-12 hours depending on your phototype, sensitivity and skin type. Your therapist will guide you with this.
Varying degrees of redness, swelling or flaking. Everyone is different and skins may differ in reaction.
Ensure the product is sealed tightly and store below 23 degrees Celsius. If you live in a very warm climate you may keep it in the fridge.
Vascular pigmentation is driven by blood vessels that are dilated and are activating the tyrosinase enzymes that will stimulate pigmentation. Cosmelan cannot treat vascularity as it cannot extend that deep into the skin. We Recommend IPL after completing the Cosmelan Protocol to shrink down those blood vessels. (You can read more about our IPL Treatment here)
You may continue with the reappearance control phase indefinitely as it has no side effects and has all the active ingredients in it for anti-ageing as well as preventing future reappearance of hyper pigmentation.
OR
You can step down to our Mesoestetic Tran3X homecare products.
Melan 130+ is superior in its ability to protect against UVB rays that actually cause the damage to the epidermis. It also contains Azelaic Acid which has a depigmenting effect and therefore works synergistically with the other products to give you even better results!
The Cosmelan peel price varies depending on individual needs and the inclusion of follow-up care products like the Mesoestetic brightening peel booster and Cosmelan 2 maintenance cream. Contact Natural Aesthetics for a detailed cost breakdown.
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27 Willie van Schoor avenue, Tygervalley Chambers, Building 5, Ground Floor, Office 1
